Important Information about percocet
Unfortunately, percocet is illegal to purchase online. While this
medicine may be the one you need, you will not be able to purchase it legally
online. We suggest seeking another strong medicine very similar like
hydrocodone/vicodin. You can find this medicine through one of the links
provided below. Also be aware of other websites that promise you can
purchase this medicine
through their website or email. If they are telling you it is available
without speaking directly to a doctor, it is either illegal or a scam.
DESCRIPTION OF PERCOCET
Inform your physican if you are pregnant or nursing.
This medication may cause dizziness, drowsiness, or blurred
vision; use caution while driving or operating hazardous machinery. Do not take
any other sedating drugs or drink alcohol while taking acetaminophen with
oxycodone.
This medication may be habit forming. Withdrawal symptoms may
occur after you stop taking it.
Inform your physician if shortness of breath or breathing
difficulty occur.
May cause nausea, vomiting or constipation; notify your
physician if these occur.
May be taken with food if GI upset occurs.
DESCRIPTION
Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate
analgesic and antipyretic which occurs as a white, odorless, crystalline powder,
possessing a slightly bitter taste. Its molecular formula is C8H9NO2. The
molecular weight is 151.17.
The oxycodone component is 14-hydroxydihydrocodeinone, a
white, odorless, crystalline powder having a saline, bitter taste. It is derived
from the opium alkaloid thebaine. Its molecular formula is C18H21NO4·HCl. The
molecular weight is 351.83.
Capsules
Each capsule, for oral administration, contains:
Acetaminophen: 500 mg
Oxycodone HCl (WARNING: May be habit forming): 5 mg*
Inactive Ingredients: Black iron oxide, corn starch, D&C yellow #10 aluminum
lake, FD&C blue #1, FD&C blue #2 aluminum lake, FD&C red #40, FD&C red #40
aluminum lake, gelatin, magnesium stearate, pharmaceutical glaze, povidone,
pregelatinized starch, propylene glycol, and titanium dioxide.
Tablets
Each tablet of Percocet contains:
Acetaminophen: 325 mg
Oxycodone HCl (WARNING: May be habit forming): 5 mg*
*5 mg oxycodone HCl is equivalent to 4.4815 mg oxycodone.
Inactive Ingredients: Microcrystalline cellulose, povidone,
pregelatinized starch, stearic acid, and other ingredients.
CLINICAL PHARMACOLOGY
The principal ingredient, oxycodone, is a semisynthetic
narcotic analgesic with multiple actions qualitatively similar to those of
morphine; the most prominent of these involve the central nervous system and
organs composed of smooth muscle. The principal actions of therapeutic value of
the oxycodone in acetaminophen; oxycodone HCl are analgesia and sedation.
Oxycodone is similar to codeine and methadone in that it
retains at least one-half of its analgesic activity when administered orally.
Acetaminophen is a non-opiate, non-salicylate analgesic and
antipyretic.
INDICATIONS
Acetaminophen; oxycodone HCl is indicated for the relief of
moderate to moderately severe pain.
DOSAGE AND ADMINISTRATION
Dosage should be adjusted according to the severity of the
pain and the response of the patient. It may occasionally be necessary to exceed
the usual dosage recommended below in cases of more severe pain or in those
patients who have become tolerant to the analgesic effect of narcotics.
Acetaminophen; oxycodone HCl is given orally. The usual adult
dosage is 1 capsule or 1 tablet every 6 hours as needed for pain.
HOW SUPPLIED
Percocet Tablets: White tablets, with one face scored and
inscribed PERCOCET, and the other face plain.
Storage: Store the capsules and tablets at controlled room
temperature (15-30°C, 59-86°F). Protect from moisture.
ADVERSE REACTIONS
The most frequently observed adverse reactions include
lightheadedness, dizziness, sedation, nausea, and vomiting. These effects seem
to be more prominent in ambulatory than in nonambulatory patients, and some of
these adverse reactions may be alleviated if the patient lies down.
Other adverse reactions include euphoria, dysphoria,
constipation, skin rash, and pruritus. At higher doses, oxycodone has most of
the disadvantages of morphine including respiratory depression.
DRUG ABUSE AND DEPENDENCE
Acetaminophen; oxycodone HCl is a Schedule II controlled substance.
Oxycodone can produce drug dependence and has the potential
for being abused. (See WARNINGS.)
DRUG INTERACTIONS
Patients receiving other narcotic analgesics, general
anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics, or other
CNS depressants (including alcohol) concomitantly with acetaminophen; oxycodone
HCl may exhibit an additive CNS depression. When such combined therapy is
contemplated, the dose of one or both agents should be reduced.
The concurrent use of anticholinergics with narcotics may
produce paralytic ileus.
WARNINGS
Drug Dependence: Oxycodone can produce drug dependence of the
morphine type and, therefore, has the potential for being abused. Psychic
dependence, physical dependence, and tolerance may develop upon repeated
administration of acetaminophen; oxycodone HCl, and it should be prescribed and
administered with the same degree of caution appropriate to the use of other
oral narcotic-containing medications. Like other narcotic-containing
medications, acetaminophen; oxycodone HCl is subject to the Federal Controlled
Substances Act (Schedule II).
PRECAUTIONS
General
Head Injury and Increased Intracranial Pressure: The
respiratory depressant effects of narcotics and their capacity to elevate
cerebrospinal fluid pressure may be markedly exaggerated in the presence of head
injury, other intracranial lesions, or a pre-existing increase in intracranial
pressure. Furthermore, narcotics produce adverse reactions which may obscure the
clinical course of patients with head injuries.
Acute Abdominal Conditions: The administration of
acetaminophen; oxycodone HCl or other narcotics may obscure the diagnosis or
clinical course in patients with acute abdominal conditions.
Special Risk Patients: Acetaminophen; oxycodone HCl should be
given with caution to certain patients such as the elderly or debilitated, and
those with severe impairment of hepatic or renal function, hypothyroidism,
Addison's disease, and prostatic hypertrophy or urethral stricture.
Information for the Patient
Oxycodone may impair the mental and/or physical abilities
required for the performance of potentially hazardous tasks such as driving a
car or operating machinery. The patient using acetaminophen; oxycodone HCl
should be cautioned accordingly.
Pregnancy, Pregnancy Category C
Teratogenic Effects: Animal reproductive studies have not been
conducted with acetaminophen; oxycodone HCl. It is also not known whether
acetaminophen; oxycodone HCl can cause fetal harm when administered to a
pregnant woman or can affect reproductive capacity. Acetaminophen; oxycodone HCl
should not be given to a pregnant woman unless in the judgment of the physician,
the potential benefits outweigh the possible hazards.
Nonteratogenic Effects: Use of narcotics during pregnancy may
produce physical dependence in the neonate.
Labor and Delivery
As with all narcotics, administration of acetaminophen;
oxycodone HCl to the mother shortly before delivery may result in some degree of
respiratory depression in the newborn and the mother, especially if higher doses
are used.
Nursing Mothers
It is not known whether the components of acetaminophen;
oxycodone HCl are excreted in human milk. Because many drugs are excreted in
human milk, caution should be exercised when acetaminophen; oxycodone HCl is
administered to a nursing mother.
OVERDOSAGE
Acetaminophen
Signs and Symptoms: In acute acetaminophen overdosage,
dose-dependent, potentially fatal hepatic necrosis is the most serious adverse
effect. Renal tubular necrosis, hypoglycemic coma, and thrombocytopenia may also
occur.
In adults, hepatic toxicity has rarely been reported with
acute overdoses of less than 10 grams and fatalities with less than 15 grams.
Importantly, young children seem to be more resistant than adults to the
hepatotoxic effect of an acetaminophen overdose. Despite this, the measures
outlined below should be initiated in any adult or child suspected of having
ingested an acetaminophen overdose.
Early symptoms following a potentially hepatotoxic overdose
may include: nausea, vomiting, diaphoresis, and general malaise. Clinical and
laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours
post-ingestion.
Treatment: The stomach should be emptied promptly by lavage or
by induction of emesis with syrup of ipecac. Patients' estimates of the quantity
of a drug ingested are notoriously unreliable. Therefore, if an acetaminophen
overdose is suspected, a serum acetaminophen assay should be obtained as early
as possible, but no sooner than 4 hours following ingestion. Liver function
studies should be obtained initially and repeated at 24-hour intervals.
The antidote, N-acetylcysteine, should be administered as
early as possible, preferably within 16 hours of the overdose ingestion for
optimal results, but in any case, within 24 hours. Following recovery, there are
no residual, structural, or functional hepatic abnormalities.
Oxycodone
Signs and Symptoms: Serious overdosage with oxycodone is
characterized by respiratory depression (a decrease in respiratory rate and/or
tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence
progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin,
and sometimes bradycardia and hypotension. In severe overdosage, apnea,
circulatory collapse, cardiac arrest, and death may occur.
Treatment: Primary attention should be given to the
reestablishment of adequate respiratory exchange through provision of a patent
airway and the institution of assisted or controlled ventilation. The narcotic
antagonist naloxone HCl is a specific antidote against respiratory depression
which may result from overdosage or unusual sensitivity to narcotics, including
oxycodone. Therefore, an appropriate dose of naloxone HCl (usual initial adult
dose 0.4-2 mg) should be administered, preferably by the intravenous route, and
simultaneously with efforts at respiratory resuscitation. Since the duration of
action of oxycodone may exceed that of the antagonist, the patient should be
kept under continued surveillance and repeated doses of the antagonist should be
administered as needed to maintain adequate respiration.
An antagonist should not be administered in the absence of
clinically significant respiratory or cardiovascular depression. Oxygen,
intravenous fluids, vasopressors, and other supportive measures should be
employed as indicated.
Gastric emptying may be useful in removing unabsorbed drug.
CONTRAINDICATIONS
Acetaminophen; oxycodone HCl should not be administered to
patients who are hypersensitive to oxycodone or acetaminophen.
